The title is the first for Iowa's active leader in coaching victories, Gene Klinge.
Waukon used a strong second half to run away from the Comets. The Indians dominated on the boards, outrebounding Charles City 51-32 with Christa Hammel and Stephanie Snitker both adding12 rebounds.
Kristyn Ferris led Charles City with 14 points while Danielle Wubbens added 12.
Waukon finishes with an unbeaten 27-0 record and wins its first-ever state title in its second appearance.
Charles City (23-3) 11 12 12 11 -- 46
Waukon (27-0) 16 17 19 19 -- 71