2021 State Qualifying Standard: 1:57.15
| 1 |  Scarlet Martin, SRIowa City West | 1:52.34 |
| 2 |  Grace Frericks, SRCedar Falls | 1:53.08 |
| 3 |  Taylor Judas, SOWaukee | 1:53.27 |
| 4 | Jessi Wigham, JR Waukee | 1:53.55 |
| 5 | Nora Kemp, SO Waukee | 1:53.97 |
| 6 | Jade Roghair, JR Iowa City West | 1:53.99 |
| 7 |  Olivia Swalley, JRJohnston | 1:55.44 |
| 8 |  Lauren Fisher, SRAmes | 1:55.62 |
| 9 | Kolby Reese, SO Iowa City West | 1:55.68 |
| 10 | Mallory Kell, JR Waukee | 1:55.90 |
| 11 | Faith Frantum, FR Johnston | 1:56.01 |
| 12 | Payden Rafferty, SO Waukee | 1:56.38 |
| 13 | Olivia Taeger, SR Iowa City West | 1:56.86 |
| 14 |  Julia Sweetman, JRDowling Catholic | 1:56.90 |
| 15 | Willa Hage, FR Waukee | 1:56.98 |